Early amplitude-integrated EEG monitoring 6h after birth predicts long-term neurodevelopment of asphyxiated late preterm infants

2nd Edition of International Congress on Pediatrics
March 26-27, 2018 Edinburgh, Scotland

Chun Ming Jiang

Hangzhou First People′s Hospital - Nanjing Medical University, China

Posters & Accepted Abstracts: J Pediatr Care

DOI: 10.21767/2471-805X-C1-006

Abstract

The present study aimed to assess the prognostic value of early amplitude-integrated electroencephalogram (aEEG) in late preterm infants who were born at a gestational age between 34 0/7 and 36 6/7 weeks for the prediction of neurobehavioral development. Late preterm infants (nā€‰=ā€‰170) with normal, mild, and severe asphyxia underwent continuous recording of aEEG for 4ā€“6 h starting 6ā€“8 h after delivery. The recordings were analyzed for background pattern, sleep-wake cycle (SWC), and seizures. Survivors were assessed at 18 months by neurological examination and Bayley Scales of infant development II. The incidence of adverse neurological outcome in the asphyxia group was significantly higher than in the normal group. For late preterm infants in the asphyxia group, abnormal aEEG pattern had a predictive potential of neurological outcomes with sensitivity of 78.57% (specificity 87.80%; positive predictive value [PPV] 68.75%; negative predictive value [NPV] 92.31%; power 85.45%). Non-SWC and intermediate SWC significantly were increased (25.45% and 52.73%, respectively) in the asphyxia group vs. the normal group. SWC pattern had neurological prognosis value in the asphyxia group with sensitivity of 64.29 % (specificity 87.80%; PPV 64.29%; NPV 87.80%; power 81.82%). Early aEEG patterns are important determinants of long-term prognosis of neurodevelopmental outcome in asphyxiated late preterm infants. [email protected]