Design, synthesis, anticancer and antimicrobial activity of new cyclohepta[b]pyridine and cyclohepta[d]pyrimidine sugar hydrazones and oxadiazolyl acyclic C-nucleoside analogs

Ibrahim F Nassar; Wael A El-Sayed; Tamer M Saleh

doi:10.21767/2472-1123-C2-006

Design, synthesis, anticancer and antimicrobial activity of new cyclohepta[b]pyridine and cyclohepta[d]pyrimidine sugar hydrazones and oxadiazolyl acyclic C-nucleoside analogs

European congress on Advanced Chemistry
July 12-13,2018 Paris ,France

Ibrahim F Nassar, Wael A El-Sayed and Tamer M Saleh

Ain Shams University, Cairo, Egypt National Research Centre, Egypt

Posters & Accepted Abstracts: J Org Inorg Chem

DOI: 10.21767/2472-1123-C2-006

Abstract

New aryl substituted cyclohepta[b]pyridine and cyclohepta[d]pyrimidine derivatives were synthesized. The sugar hydrazones of both synthesized pyridine and pyrimidine were also prepared. In addition, the 1, 3, 4-oxadiazolyl acyclo C-nucleoside analogs of the pyridine system were synthesized. The anticancer and antimicrobial activities of some of the prepared compounds were studied. Two compounds showed high activity against MCF-7, HEPG-2, and HCT-116 cell lines. The predicted binding patterns of the three of the prepared compounds as possible antagonists against ERα were investigated.