Design, development and evaluation of topical liposomes of benzoyl peroxide and herbal drug resveratrol for treatment of acne

Joint Event on 3rd World Congress on NATURAL PRODUCTS CHEMISTRY AND RESEARCH & 12th WORLD PHARMA CONGRESS
October 16-18, 2017 Budapest, Hungary

Manju Kamra ,Anupama Diwan , Satish Sardana

Hindu College of Pharmacy, India

Posters & Accepted Abstracts: Am J Ethnomed

DOI: 10.21767/2348-9502-C1-003

Abstract

Liposomal formulations have been successfully used in the treatment of a number of dermatological diseases including acne. Benzoyl peroxide is a potent antibacterial used commonly for the treatment of acne either alone or in combination. But it suffers from side effects like skin redness, irritation, itching, and oedema. In this present study benzoyl peroxide alongwith a herbal drug Resveratrol was encapsulated into liposomes, for topical applications .Pre Formulation and compatibility studies of both drugs by UV and FT-IR , DSC and XRD indicated no incompatibility between both drugs and excipients . .Liposomes were prepared by thin film hydration technique using phospholipid, cholesterol and drugs in different ratios. Concentration of phospholipid , cholesterol and Hydroxy Propyl- β-Cyclodextrin was optimized by Experimental response surface design (Box Behnken Design (BBD)). These formulations were prepared and evaluated for the Entrapment Efficiency (EE% ) of benzoyl peroxide and resveratrol. The optimized liposomal formulations was further evaluated for particle size , zeta potentia , FT -IR, XRD and TEM . The particle particle size with PDI value less than 0.3 indicated uniform particle size distribution , –ve zeta potential indicated Brownian motion stability between the particles and TEM showed the presence of outer coating of bilipid layer entrapping the drugs with an optimum size in the range of 150-350 nm .Liposomal suspension was lyophilized to make it more stable.

Biography

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