Journal of Vascular and Endovascular Therapy

Chronic Venous Insufficiency: A new concept to understand pathophysiology at the microvascular level-a pilot study

7^th Edition of World Congress & Exhibition on VASCULAR SURGERY
November 29-30, 2021 Webinar

*Omar Mutlak, M. Aslam, N. Standfield

Imperial College London, UK

Keynote: J Vasc Endovasc Surg

Abstract

Objectives: The real mechanism for the development of the later stages of chronic venous insufficiency still remains unclear. Venous hypervolemia and microvascular ischemia have been reported to be the consequences of venous insufficiency. The aim of this study was to investigate the effects of induced venous hypovolemia by dorsiflexion exercise in patients with venous leg ulcers. Methods: Thirty-six participants, all of whom had an ankle brachial pressure index between 0.8 and 1.2 mmHg, were chosen for this study. The participants were divided into two groups: Group A, a non-exercise group and Group B which performed regular exercise in the form of dorsiflexion. The basic assessment, including the history and examination, ankle-brachial pressure index (ABPI), Duplex scan and tcPO2 measurements was performed on two occasions at the beginning of the trial and after three months. Results: The tcPO2 level was low in the beginning in all the subjects, but the picture was different at the end of the trial. There was a significant increase in the tcPO2 level (p<0.001) in the patients who performed exercise while there was no difference in the measurements (p>0.05) in the non-exercise group. Conclusions: Induced venous hypovolemia through regular evacuation of the peripheral venous system improved tissue oxygenation at skin level. Venous hypervolemia may be the main contributing factor for the development of venous hypoxia and microvascular ischemia.

Biography

Omar Mutlak grew up in Iraq and received his Bachelor’s degree from the University of Basra. He had his higher surgical training in Iraq. He joined equivalent higher surgical training program in the UK. He became a member of the Royal College of Surgeons of Edinburgh in 2007. He was appointed as Honorary Senior Clinical Research Fellow in Imperial College London and works as a General Surgeon at Imperial College Healthcare NHS Trust, UK. He awarded DIC and MSc in surgical science from Imperial College London, UK in 2008. He Obtained His MD (Res) degree from Imperial College London, UK in 2017.