Kyung-Sik Song, Eun-Ju Yang, Doohyun Lee, Wonhwa Lee, Jong-Sup Bae and Taeho Lee
Seoul National University, Republic of Korea
Posters & Accepted Abstracts: Am J Ethnomed
Despite intensive investigation of molecular mechanisms underlying the pathogenesis of sepsis, many aspects of sepsis remain unresolved, which hamper the development of appropriate therapeutics. Abronia nana is an ornamental plant belonging to Nyctaginaceae, its pharmacological potential, especially against septic responses, has not been established well. In the present study, we isolated a rarely new compound 1,3-dihydroxy-2-methyl-11H-benzofuro[2,3-b]chromen-11- one (LDH1609) from Abronia nana. LDH1609 was investigated for its potential activities against HMGB1-mediated septic responses. The data showed that LDH1609 effectively inhibited the Lipopolysaccharide (LPS)-induced release of High Mobility Group Box-1 (HMGB1). The HMGB1-mediated septic responses were also significantly suppressed by LDH1609, including hyperpermeability, leukocyte adhesion and migration, and cell adhesion molecule expression. In addition, LDH1609 inhibited the HMGB1-mediated production of Tumor Necrosis Factor-α (TNF-α) and Interleukin (IL)-6, the activation of nuclear factor-κB (NF-κB), and Extracellular Signal-Regulated Kinase (ERK) 1 and ERK2. These results demonstrate that LDH1609 might be applied to develop the potential therapeutic agents for various severe vascular inflammatory diseases through the inhibition of the HMGB1 signaling pathway.
Kyung-Sik Song is a professor at Seoul National University, Republic of Korea. He has his expertise in Medicinal Chemistry. He has published more than 50 papers in peer reviewed international journals.
E-mail: [email protected]