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Tissue Science 2019
June 17-18, 2019
London, UK
Advances in Tissue
Engineering and
Biomaterials Science
13th Edition of International Conference on
Journal of Biomedical Sciences
ISSN: 2254-609X Page 26
Stimuli responsive lipid coated mesoporous silica
nanoparticles for drug delivery
Muhammad Umair Amin, Sajid Ali, Imran Tariq, Muhammad Yasir Ali,
Shashank Reddy Pinnapreddy, Jana Brüßler and Udo Bakowsky
Philipps-Universität Marburg, Germany
Immediate release of the drug from the drug delivery
carrier after cellular uptake is a big challenge.
Premature leakage of the chemotherapeutics during
circulation, causing side effects to healthy tissue, is even
more relevant. Stimuli responsive drug delivery systems
have addressed these issues and have become more
attractive in last few years. Physical stimuli including
ultrasound (US) due to its non- invasive nature are
considered very safe and effective. Mesoporous silica
nanoparticles due to their salient features are very
suitable for drug delivery to tumor cells. These features
include larger surface area, hydrophilic and hydrophobic
nature, tailorable pore size and pore volume, inner and
outer surface for attachment, mechanical strength and
non-toxic nature. By combining distinguishing features
of liposomes to mesoporous silica nanoparticles very
satisfactory results can be achieved. We have developed
an US responsive drug delivery system where we have
used mesoporous silica nanoparticles as a drug carrier,
doxorubicin as a model drug, perfluoropentane (PFP) as
an US responsive material and liposomes as gatekeeper.
The release of the drug was successfully triggered by
US due to the disruption of low boiling point PFP inside
pores, building up pressure and causing the immediate
release. This immediate release was also observed in
cell culture experiments where our system has produced
more cytotoxic effects to tumor cells as compared tonon-
US carriers. Lipid coating to MSNPs not only provided
the gate keeping effects but also enhanced the cellular
uptake of the carrier.
Biography
Muhammad Umair Amin is Pharmacist by profession and has
done his Master in Pharmaceutics. Currently he is doing PhD
under DAAD/HEC Pakistan Scholarship program, in the super-
vision of Prof. Dr. Udo. Bakowsky at Department of Pharma-
ceutics and Biopharmaceutics, Philipps-Universität Marburg,
Marburg, Germany. The major area of interest is development
of drug carrier systems and characterization. Primary research
goals are directed toward the fabrication of mesoporous sil-
ica nanoparticles and targeting of nanoparticles loaded with
anti-cancer drugs to resistant hypoxic tumor cells. He has an
experience in research, teaching and administration in educa-
tion institutions.
Muhammad Umair Amin et al., J Biomedical Sci 2019, Volume 08