22 / 46
4
t h
E u r o S c i C o n C o n f e r e n c e o n
Neurology & Neurological
Disorders
Neurology 2018
J u l y 1 2 - 1 3 , 2 0 1 8
P a r i s , F r a n c e
Page 84
Journal of Neurology and Neuroscience
ISSN: 2171-6625
S
leep disorders have a variable spectrum and are present in all forms of
dementia, especially in Alzheimer's disease (AD). Elderly patients generally
present with sleep disturbances, but this association is more frequent in
patients with AD. The aim of this work was to perform a narrative review on
the alterations in sleep that occur in patients with AD. A literature review was
conducted using MEDLINE, LILACS, Web of Science, Scopus, Science Direct
as databases and Alzheimer disease, sleep wake disorders, dyssonias as
descriptors. It has been observed that sleep disorders are framed as one of
the symptoms of AD, in addition to being related to physiological and genetic
patterns. The main symptoms are getting up at night and waking up at night
thinking it is day. The incidence of these symptoms was detected in patients
with worse cognitive and functional status, lower socioeconomic status
and depression. The relationship between insomnia, aggression, paranoid
delusions and anxiety was observed. Recent studies have seek to clarify
the etiology of sleep disorders, considering associations between absence
of healthy sleep with greater deposition of amyloid load in brain regions
such as angular gyration, frontal medial orbital cortex, cingulate gyrus and
precuneus. Disorders of orexin levels in the cerebrospinal fluid in patients
with AD were observed, promoting a change in the activation of the Wake-
active monoaminergic system and the deactivation of the REM-on cholinergic
groups, reducing sleep homeostasis. Lower body temperature at the end of
the day causes disorders of the circadian rhythms in AD and a deficiency in
the negative regulation of the proximal blood flow of the daytime skin has
been found which may also affect the process. These researches initiate the
development of new treatments, which will impact the patient's cognition
and, consequently, their quality of life. We conclude, therefore, that the sleep
disorders are one of the fundamental clinical aspects that must be evaluated
in AD patients, specially due to its role as a prognostic changer for the disease.
Biography
Tatiana Paschoalette Rodrigues Bachur is a Pharmacist,
graduated from the Pharmaceutical Sciences Course of the
Federal University of Ceará (UFC-1999) and has completed her
Masters in Pathology from the Federal University of Ceará (UFC-
2007). She is a Professor of the Medicine Course of the State
University of Ceará - UECE, Brazil, Coordinator of specialization
courses in the distance learnig modality and collaborates in the
Group of Studies in Neuroinflammation and Neurotoxicology
– GENIT from UECE. She develops studies in Toxicology,
Pharmacology and Tropical Diseases and is a reviewer of
scientific journals and project leader.
tatiana.bachur@uece.brTatiana P. R. Bachur
4
, Gleiry Y. R. Cardoso
1
, Juliana C. Costa
2
,
Matheus E. S. Lima
3
, Gislei F. Aragao
5
¹ Gleiry Y. R. Cardoso (State University of Ceará, BR)
² Juliana C. Costa (State University of Ceará, BR)
3
Matheus E. S. Lima (State University of Ceará, BR)
4
Tatiana P. R. Bachur (State University of Ceará, BR)
5
Gislei F. Aragão (Federal University of Ceará, BR)
Tatiana P. R. Bachur4 et al., J Neurol Neurosci 2018, Volume: 9
DOI: 10.21767/2171-6625-C1-009
Sleep disorders in Alzheimer disease