neurology-2018-posters-abstracts

t h

E u r o S c i C o n C o n f e r e n c e o n

Neurology & Neurological

Disorders

Neurology 2018

J u l y 1 2 - 1 3 , 2 0 1 8

P a r i s , F r a n c e

Page 78

Journal of Neurology and Neuroscience

ISSN: 2171-6625

nflammation is a defense reaction of the body's immune system to harmful

external aggression such as a bacterial infection. Moreover, it is an important

source of oxygen radicals produced directly by activated phagocytic cells that

are the site of a phenomenon called oxidative explosion. This work was done to

find out whether infection with early lipopolysaccharide (LPS) administration

can result in changes in nitric oxide levels and lipid peroxidation in the central

nervous system, specifically prefrontal cortex and the hippocampus. Male and

female wistar rats at 7 days of age were divided into 2 groups: a control group

receiving an intraperitoneal injection (ip) of PBS, the second group treated

with LPS (250 μg / kg, ip). The results show that the rate of nitric oxide in the

hippocampus in a physiological state during the 3 days postnatal (7.8, and 9)

increases in females at the age of 8 days and decreased later, but in males, the

rate increases with age. Also at the level of chlorpyrifos (CPF), we observed

increased rate of nitric oxide in both sexes without any sexual dimorphism.

The rate of lipid peroxidation at a physiological state is increased at the age

of 8 and 9 days for both sexes compared to 7-day-old rats. But once after an

infection induced by the LPS, it was observed that the rate of lipid peroxidation

in the hippocampus and prefrontal cortex at an age of 7 days is increased for

both sexes, but on the 8th day we found a sexual dimorphism and at PDN9 age

the lipid peroxidation rate is increased in males than females. It is concluded

that postnatal injection of LPS induces a decrease in nitric oxide rate, and an

increase in lipid peroxidation in the prefrontal cortex and the hippocampus.

Biography

Najlae Elfathi has completed his/her Bachelor's degree in

Physics Chemistry in 2010. In 2014 she, did life science in

biology, & in 2017 she did Master on neurocognition human

and health of the population, and now, she is pursuing PhD (1st

Year) on early neuroinflammation and glial activation

Najlae Elfathi, Inssaf Berkiks, Abdelhalim Mesfioui and

Aboubaker Elhessni

Université Ibn Tofail, Kenitra, Morroco

Najlae Elfathi et al., J Neurol Neurosci 2018, Volume: 9

DOI: 10.21767/2171-6625-C1-009

Sexual dimorphism of nitrogen monoxide rate and lipid

peroxidation at early age: observation after 4h, 24h, 48h of

infection with lipopolysaccharide