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Volume 4, Issue 2
American Journal of Ethnomedicine
ISSN 2348-9502
Natural Products Congress & World Pharma Congress 2017
October 16-18, 2017
3
rd
World Congress on
NATURAL PRODUCTS CHEMISTRY AND RESEARCH
&
12
th
WORLD PHARMA CONGRESS
October 16-18, 2017 Budapest, Hungary
A new 1,3-dihydroxy-2-methyl-11H-benzofuro[2,3-b]chromen-11-one isolated from
Abronia nana
,
inhibits High mobility group box-1 (HMGB1)-induced septic responses
Kyung-Sik Song, Eun-Ju Yang, Doohyun Lee, Wonhwa Lee, Jong-Sup Bae and Taeho Lee
Seoul National University, Republic of Korea
D
espite intensive investigation of molecular mechanisms underlying the pathogenesis of sepsis, many aspects of sepsis
remain unresolved, which hamper the development of appropriate therapeutics.
Abronia nana
is an ornamental plant
belonging to Nyctaginaceae, its pharmacological potential, especially against septic responses, has not been established
well. In the present study, we isolated a rarely new compound 1,3-dihydroxy-2-methyl-11H-benzofuro[2,3-b]chromen-11-
one (LDH1609) from
Abronia nana
. LDH1609 was investigated for its potential activities against HMGB1-mediated septic
responses. The data showed that LDH1609 effectively inhibited the Lipopolysaccharide (LPS)-induced release of High Mobility
Group Box-1 (HMGB1). The HMGB1-mediated septic responses were also significantly suppressed by LDH1609, including
hyperpermeability, leukocyte adhesion and migration, and cell adhesion molecule expression. In addition, LDH1609 inhibited
the HMGB1-mediated production of Tumor Necrosis Factor-α (TNF-α) and Interleukin (IL)-6, the activation of nuclear
factor-κB (NF-κB), and Extracellular Signal-Regulated Kinase (ERK) 1 and ERK2. These results demonstrate that LDH1609
might be applied to develop the potential therapeutic agents for various severe vascular inflammatory diseases through the
inhibition of the HMGB1 signaling pathway.
Biography
Kyung-Sik Song is a professor at Seoul National University, Republic of Korea. He has his expertise in Medicinal Chemistry. He has published more than 50 papers
in peer reviewed international journals.
kssong@knu.ac.krKyung-Sik Song et al., American Journal of Ethnomedicine, 4:2
DOI: 10.21767/2348-9502-C1-003