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Journal of Infectious Diseases and Treatment
ISSN: 2472-1093
7
t h
E u r o s c i c o n C o n f e r e n c e o n
Clinical Pathology
and Epidemiology
F e b r u a r y 2 7 - 2 8 , 2 0 1 9
P r a g u e , C z e c h R e p u b l i c
Clinical Pathology & Epidemiology 2019
I
ntroduction:
There is increasing evidences that favor the prenatal beginning of schizophrenia. These evidences point toward
intra-uterine environmental factors that act specifically during the second pregnancy trimester producing a direct damage of the
brain of the fetus. The current available technology doesn't allow observing what is happening at cellular level since the human
brain is not exposed to a direct analysis in that stage of the life in subjects at high risk of developing schizophrenia.
Methods:
In 1977, we began a direct electron microscopic research of the brain of fetuses at high risk from schizophrenic
mothers in order to finding differences at cellular level in relation to controls.
Results:
In these studies we have observed within the nuclei of neurons the presence of complete and incomplete viral particles
that reacted in positive form with antibodies to herpes simplex hominis type I [HSV1] virus, and mitochondria alterations.
Conclusion:
The importance of these findings can have practical applications in the prevention of the illness keeping in mind its
direct relation to the aetiology and physiopathology of schizophrenia. A study of the gametes or the amniotic fluid cells in women
at risk of having a schizophrenic offspring is considered. Of being observed the same alterations that those observed previously
in the cells of the brain of the studied foetuses, it would intend to these women in risk of having a schizophrenia descendant,
previous information of the results, the voluntary medical interruption of the pregnancy or an early anti HSV1 viral treatment as
preventive measure of the later development of the illness.
segundo@infomed.sld.cuDirect evidence of viral infection and
mitochondrial alterations in the brain of fetuses
at high risk for schizophrenia
Segundo Mesa Castillo
Psychiatric Hospital of Havana, Cuba
J Infec Dis Treat 2019, Volume: 5
DOI: 10.21767/2472-1093-C1-009