Abstract

Stem cells therapy is a new modality for treatment of heart failure, myocardial infarction, intractable angina, and during cardiac surgery. Since 2004 there are more than 300 phase 1, phase 2 and phase 3 trials showing the safety and efficacy of this therapy. Different types of stem cells used mainly bone marrow derived, adipose derived and cardiac derived. There were 4 routes of injections used including direct cardiac, subendo cardial, intracoronary and intravenous injections. There are many published meta-analysis of randomized trials showing they are safe, effective, with improvement in left ventricle function, patients symptoms and survival benefit. We believe stem cells therapy will become a recognized and routinely used in cardiology in the coming near future.