Catharanthus roseus is notable for its pharmacological importance. The current examination means to decide the antifungal movement of Catharanthus roseus against different clinically critical contagious strains (Candida albicans, Aspergillus fumigatus, Aspergillus niger, Fusarium moniliforme). Evaluation of antifungal movement of Catharanthus roseus was finished by paper plate dissemination strategy. In this examination, three extraction media (Ethanol, Acetone, and Aqueous) were utilized. Information portrays that the example of hindrance generally rely on extraction dissolvable. Natural concentrates gave more intense antifungal action when contrasted with fluid concentrates. Leaves of Catharanthus roseus showed huge restraint. Leaves of Catharanthus roseus showed magnificent movement against Fusarium moniliforme in ethanolic removes. Writing overview had not mirrored any movement of Catharanthus roseus against Fusarium moniliforme along these lines; antifungal action of Catharanthus roseus against Fusarium moniliforme is accounted for interestingly. The plant separate demonstrated viable against chose contagious strains A. fumigatus, C. albicans, A. niger, F. moniliforme. Ethanol dissolvable is a superior extraction dissolvable as contrasted with CH3)2CO. MIC goes between 25 µg/µl to 50 µg/µl. Control fill in as negative control and anti-fungicide as certain control. Greatest restraint was seen in ethanolic leaf concentrate of C. roseus against F. moniliforme for example 2.45 cm (59.18 %) at 90 µl conc. Antifungal movement against plant pathogenic parasites F. moniliforme is moreover revealed interestingly.