Abstract

Statement of the problem: Cancer is the multifaceted disease which deals with the proliferation of tumor cells and becomes fatal for thousands of lives because of its treatment that still remains challenging for the scientific community. Only nanoparticle is not subjected to cancer treatment Methodological and theoretical orientation: At the same time nanotechnology is becoming the emerging field of recent developments in medicine which is very essential part for failure of pharmaceuticals now-a-days. In this study, silver oxide nanoparticles has been synthesized through co-precipitation method and functionalized with ant-cancer drug. This synthesis is confirmation via different characterizations X-ray Diffraction (XRD), Fourier Transformed Infrared (FTIR), Scanning Electron Microscopy (SEM), Energy Dispersive X-ray (EDX) and Ultraviolet (UV) spectroscopy and uses them against cancer cell lines that will help to opine the treatment of cancer and save thousands of precious lives. Findings: Silver oxide nanoparticles have improved the drug delivery and synergistic effect with drug. One of the functionalized formulations shows better results even at very low concentrations on HepG2 cancer cell lines with very low IC50 as compared to others. Similarly this combination showed very low relative percentage viability and very few number of cancer cells shown when used against cancer cell lines. Such kind of combination of nanoparticle to anti-cancer drug will provide a very convenient ways to find out the cancer treatment. Conclusion and significance: The combined effect of nanoparticles with anti-cancer drug has been observed as a very effective treatment against cancer.