Voltammetric Analysis of ATPase-inhibitor Using Redox Mediator Platform: Application in Biological Fluids

In this study, the oxidation of rabeprazole sodium (RAB Na⁺), a widely used anti-ulcer drug, was investigated at a modified poly (bromocresol green)/ pencil graphite electrode (poly (BCRG)/PGE). A disposable, sensitive and selective electrochemical platform is proposed for the determination of RAB Na⁺ by recording its cyclic voltammetry (CV) and square wave adsorptive voltammetry (SWV) in Britton-Robinson buffer solution at pH of 7.0 using the modified PGE. The poly BCRG/PGE displayed a good electrochemical behaviour with significant enhancement of the peak current compared to the bare PGE. Under experimental conditions, the modified electrode had a linear response range from 10-180 × 10^-8 M and 3-330 × 10^-7 M for SWV and CV, respectively. The detection limit was found to be 3 × 10^-8 M and 1 × 10^-7 M for SWV and CV, respectively. These voltammetric methods were successfully applied for the direct determination of RAB Na⁺ in real samples. The effect of various interfering substances on the RAB Na⁺ peak current was also investigated.

Author(s): Pakinaz Youssef Khashaba, Hassan Refat Hassan Ali, Mohamed Mahmoud El-Wekil

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