Dengue is an acute viral infection in tropical and subtropical regions. Dengue is a major public health crisis in numerous regions of the world. The aim of this research is to study the Medication Therapy Management (MTM) of patients with dengue admitted in ESI hospital, Bangalore. Also, to improve the quality of life of patients, to address issues of polypharmacy, preventable adverse events, medication adherence and medication misuse and to improve outcomes by helping people to better understand their health conditions and the medications used to manage them.It is a descriptive, observational, and interventional study. The data is collected through suitably designed forms and by direct interaction with the patients as well as their care takers. The study cohort consists of 57 patients. All the patients in the study population are treated with Paracetamol, Pantoprazole and Cephalosporin and Methyl prednisolone, IV fluids and Vitamin K. In our study maximum drug interactions are seen with Dexamethasone and Pantoprazole in 27 (47.36%) patients. Minimum drug interactions were seen with Ciprofloxacin and Ondansetron as well as Ciprofloxacin with Vitamin K and Dexamethasone with Ciprofloxacin among 3 (5.26%) patients. Process measures (type and frequency of drug therapy problems detected), economic measures (number of medications dispensed), and humanistic measures, (patient satisfaction with services) were the main outcomes in this process after providing MTM services. During hospitalization, patients improved their quality of life and their state of illness reduced. MTM provided safe and effective medication. Successful MTM assisted the patients to manage their own treatment.