The Role of Thymic Stromal Lymphopoietin in the Pathogenesis and Treatment of Severe Uncontrolled Asthma

Asthma is a highly prevalent chronic airway disease, affecting more than 358 million individuals globally [1], and it is the most common chronic inflammatory respiratory disease in children [2]. Asthma has been classified cytological depending on the predominant leucocyte count in induced sputum, and biomarkers of airway inflammation into eosinophilia, neutrophil, mixed granulocytic, and paucigranulocytic phenotypes [3, 4].

Approximately 40-60% of patients with severe asthma have eosinophilic phenotype [5-9], which is uncontrolled on high-dose inhaled corticosteroids (ICS), and long-acting β2-agonists (LABA), and leukotriene receptor antagonists (LTRA) [10,11].

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