The Ovarian Congestion after “U-74389G” Administration in Rats

Object: The possible recessing capacity of the antioxidant drug “U-74389G” was studied in a rat model. It included the evaluation of the mean Ovarian Congestion (OC) lesions after induced ovarian Ischemia-Reperfusion (IR) injury. Methods: The 40 used rats of mean mass 231.875 g were classified at 2 evaluation endpoints: one of 60 min for groups A and C and one of 120 min for groups B and D after reperfusion. The U-74389G was administered only in groups C and D. Results: U-74389G administration non-significantly declined the OC lesions scores by 0.6 mild [-1.208205–0.0082055] (p=0.0832). Reperfusion time non-significantly augmented the OC lesions scores by 0.4 without lesions [0.7678806–0.56788075] (p=0.2860). The interaction of U-74389G administration with reperfusion time non-significantly declined the OC lesions scores by 0.2727273 without lesions [-0.6477081–0.1022535] (p=0.1492). Conclusion: The U-74389G administration presented a no significant short-term recess direction for OC scores without lesions alteration. A more long-term study time or an enhanced U-74389G dose may outcome more significant effects.

Author(s): Τsompos C, Panoulis C, Τοutouzas K, Triantafyllou A, Ζografos G and Papalois A

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