Introduction: Colon drug delivery system has witnessed a huge interest for developing drugs for local treatment. Colonic region is important for drug delivery and absorption. The benefits include low enzymatic activity, high residence time and treatment of colonic disorders such as ulcerative colitis, Crohn disease, carcinoma and several infections. In order to design a colonic drug delivery system, factors such as colon pH, colonic microflora, transit time and drug absorption should be considered. Method: Mesalazine was prepared as solid dispersions using polyvinylpyrrolidone (PVP) and methacrylic acid –methacrylate copolymer (Eudragit S 100). Differential Scanning Calorimetry (DSC), Thermogravimetric analysis (TGA) and X-ray diffraction (XRD) were used to examine and identify the drug polymorphism. Spectroscopy analysis (FT-IR) was used to identify any possible interaction between the polymers and the drug. In-vitro dissolution studies were performed to determine the percentage release of the formulations. According to ICH requirements, stability studies for the drug product were accomplished. 1. Introduction In the past relatively few decades, the power of colonic diseases has extended far and wide, mentioning the effective close by treatment of colonic ailments for continuously helpful and increasingly secure prescription medicines. Among colonic ailments, colorectal malady (CRC) causes the most harmful development related passings in Europe (accounting in excess of 200,000 passings yearly) and it is the third most by and large examined threatening development generally speaking . The recurrence of provocative gut disease (IBD) is in like manner extending at an upsetting rate in effectively low-recurrence zones, for instance, Asia . In this way, the ground-breaking treatment of colonic disorders has become a huge by and large open human administrations issue. For the close by treatment of colonic illnesses, colon-concentrated on cure transport systems have been successfully looked for after since normal non-concentrated on treatment may have lamentable indications and low sufficiency in light of the central digestion of medicine before showing up at the target site . Despite the topical transport, colon-concentrated on calm movement structures are furthermore pertinent to improve the bioavailability of medications frail against acidic and also enzymatic destabilization in the upper gastrointestinal (GI) tract, particularly macromolecules, for instance, proteins and peptides on account of lower protease activity in the colon . But colonic movement of macromolecules has been examined less broadly taken a gander at to little particles, determined research may reveal its potential as an effective oral transport system for macromolecules. Colon concentrated on calm transport structures are planned to explicitly release a drug considering the colonic condition without awkward medicine release in the upper GI tract. Thusly, it is fundamental to consider the physiological properties of the colon and the microenvironment incorporating disease site(s) for the successful improvement of colon-concentrated on cure movement systems. At the point when everything is said in done, GI tract encounters dynamic changes in motility, fluid substance, enzymatic activity, and pH from the stomach to the stomach related framework . Furthermore, the microenvironment including a disease site in the colon is particularly not exactly equivalent to ought not out of the ordinary and sound regions. Patients with colonic diseases produce elevated levels of responsive oxygen species (ROS) and searing cytokines, have a disproportion of critical cell fortifications, and experience the evil impacts of mucosal injury . Given that the pathophysiological changes in the microenvironment enveloping The International Debate on Spray Dried Drug Delivery Systems for Ileo-Colonic Targeting Name: Klesta Durraj Kingston University London, KT1 2EE, United Kingdom 2020 Vol. 1, Iss. 2 Extended Abstract Journal of Chemical Biology & Pharmaceutical Chemistry 2020 Vol. 1, Iss. 2 Extended Abstract Journal of Chemical Biology & Pharmaceutical Chemistry sickness regions should be considered during definition improvement, distinctive definition approaches have been researched to smooth out the colonic prescription transport, including pH-fragile systems, impetus initiated structures, and appealingly decided systems. To improve the unequivocality at illness goals, receptor-interceded structures have moreover been inspected, which uniquely work together with express receptors overexpressed at the site(s) of the affliction. This review spread later movements in various arrangement approaches in organizing colon-concentrated on sedate transport structures likewise, their pharmaceutical applications. 2. Plan Approaches for Colon Targeted Drug Delivery 2.1. pH-Dependent Drug Delivery Systems The colon shows a decently higher pH than the upper GI tract, and this can be used as a concentrating on procedure for colonic drug movement. As necessities be, a colon-centered around sedate movement structure is arranged by using pH-subordinate polymers, for instance, cellulose acidic corrosive determination phthalates (CAP), hydroxypropyl methyl-cellulose phthalate (HPMCP) 50 and 55, copolymers of methacrylic destructive and methyl methacrylate (e.g., Eudragit® S 100, Eudragit® L, Eudragit® FS, and Eudragit. Particularly, Eudragit® polymers are the most extensively used fabricated copolymers for colonicmedication transport that offer mucoadhesiveness and pH-subordinate drug release [13,14]. The ideal polymer should have the choice to withstand the low pH of the stomach and the proximal bit of the little stomach related framework yet be separated by the pH of the terminal ileum and the colon. In this manner, cure movement structures secured with pH-subordinate polymers having a crumbling edge of pH 6.0–7.0 are depended upon to defer the calm breaking down and prevent less than ideal prescription release in the upper GI tract before showing up at colonic goals .Regardless, this pH-subordinate system has displayed colossal variability in sedate release what’s more, disillusionment in vivo on account of the enormous between and intra-subject variability in fundamental parameters including pH, fluids volumes, GI travel times, and motility In addition, pH extents of GI tract can be basically balanced by diet, sickness state, water affirmation, and microbial assimilation . For example, patients with ulcerative colitis show dynamically acidic colonic pH appeared differently in relation to sound individuals, heading to divided drug release from enteric secured systems at the target site . Along these lines, the dynamic pH change by various internal and outside factors may decrease the profitability of pH-subordinate medicine release structures, consistently inciting inadequately site-specific drug release. Ibekwe et al. moreover revealed that Eudragit® S covering was not sensible for the colon-concentrated on sedate release, either as a result of crumbling disillusionment at the target site or early drug release before the goal site. In the resulting human examinations, Ibekwe et al. certified the nonattendance of site-explicit medicine appearance of Eudragit® S secured tablets, suggesting that disintegrating of these tablets is affected by different physiological segments including gastrointestinal pH, feed status, and intestinal travel time. To overcome this requirement of pH-subordinate movement structures, there have been tries to use the mix of pH-subordinate systems with other transport systems including time-subordinate systems moreover, substance enacted systems. For example, Eudragit® S were blended in with high-amylose maize starch for the compromise of pH-subordinate structure and colonic microbial degradation systems Liu et al. got twofold covering approach by using the fundamental watery course of action of Eudragit® S with buffering administrators for interior layer and the normal plan of Eudragit® S for outer layer, stimulating the medicine breaking down at pH > 7. Subsequently, Varum et al. surveyed in vivo execution of this twofold canvassed structure in individuals, indicating continuously solid separating of twofold shrouded tablets principally in the lower intestinal tract. Hashem et al. made microspheres uniting time-and pH-subordinate structures for colonic movement of prednisolone. By using a blend of Eudragit® S and ethyl cellulose, they achieved progressively noticeable colonic prescription transport while thwarting unfavorable drug release in the upper stomach relat- ed tract .Eudracol® is another instance of a multi-unit development giving concentrated on calm transport to the colon, with deferred and uniform prescription release. This system relies upon covering the pellet with Eudragit® RL/RS and Eudragit® FS 30D, giving colon-express medicine release in a pH-and time-subordinate way . As a rule, facilitated structures of the unmistakable release initiating frameworks are progressively valuable to vanquish the pathophysiological irregularity appeared differently in relation to pH-subordinate system alone, in spite of the way that there is in spite of everything necessity for extra improvement. Moreover, nano-/littler scope particles also hold mind blowing potential for unequivocally concentrating on fueled colonic tissues and improve quiet take-up. As necessities be, various subtleties that have united a pH-subordinate structure with particle size diminishing have been created for colon-concentrated on calm movement.