The Influence of the Type and Concentration of Alcohol on the Rheological and Mucoadhesive Properties of Carpobol 940 Hydroalcoholic Gels

The objective of this work was to study the influence of type and concentration of the alcohol (ethyl and isopropyl alcohol) on the rheological and mucoadhesive properties of carbopol 940 gel formulations. The rheological and mucoadhesive properties of the systems were investigated by means of rheological analysis. The mucoadhesive properties were demonstrated by viscosity enhancement (η enhance), bioadhesion force (Fb) and relative viscosity (η rel). The viscosity, flow index and consistency index were found to be significantly influenced by type and concentration of alcohol added. Flow index was directly related to alcohol concentration while the consistency index was inversely related to alcohol concentration. The force of bioadhesion was found to be promoted by increasing concentration of ethyl alcohol up to 50% and isopropyl alcohol up to 30%. It was concluded that 30% is the optimum concentration of the alcohol in hydroalcolic systems is 30% and this concentration provide higher viscosity of Cp 940 gel with ethyl alcohol while with isopropyl alcohol provide strong mucoadhesive properties.

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