The Effect of Anti-epileptic medication on Visual voltage in Patients with Generalized Tonic-clonic Seizures: A Prospective Case controlled Study, Extended Abstracts

Abstract:
The most purpose of the current study was to see
whether or not anti-epileptic medication induce any
abnormal changes within the visual voltage (VEP)
patterns. ways and material: This prospective case
controlled study was done at the Neurology
Department of King Abdulaziz University Hospital,
Jeddah, Asian nation (between Gregorian calendar
month 2013 and Dec 2014). The study subjects were
divided into cases and controls; with the case cluster
subjects being those brain disease patients receiving
anticonvulsant medication. victimization the Visual
induced Potentials (VEPs), management and case
subjects were compared with relevance the values of:
Latency N75, Latency P100 and Amplitude P100.
Results: A statistically vital distinction was seen
between the controls and therefore the subjects
receiving anticonvulsant double and triple drug
therapy; with relevance the worth of Latency P100 (Pvalue
zero.042 and 0.044 respectively). The analysis of
variances (ANOVA) unconcealed a statistically vital
distinction (P-value zero.007 and 0.038) with
relevance the mean countless Latency N75 and
therefore the mean countless Amplitude P100; in
relevance age; between the controls and therefore the
case cluster patients receiving anti-epileptic
monotherapy. A statistically vital distinction (p=0.01)
was noted with relevance Latency N75 associated with
age, between the controls and patients receiving
anticonvulsant double medical aid. a major distinction
was additionally noted in Latency P100 mean scores
associated with age (p=0.05). A gender-wise
comparison unconcealed a statistically vital
distinction, within the mean countless Latency P100,
with the distinction showing a male predilection
Conclusion: Anti-epileptic medication will induce
abnormalities within the VEP patterns. Age and gender
ar factors that may influence the prevalence of such
abnormalities; in relevance the quantity of antiepileptic
medication taken by the patients. Future
studies ar suggested to guage the impact of the kind
and length of brain disease, in inflicting VEP
connected abnormalities.
A total of eighty healthy subjects not victimization any
anti-epileptic medication were chosen for the
management cluster. The management cluster subjects
were recruited from among the laboratory personnel,
clinic employees and medical students. cardinal
subjects were feminine and thirty two were male, with
ages starting from half-dozen to ninety seven years
recent. Visual voltage (VEP), visual induced response
(VER) and visual induced brain wave (VECP) ar
similar terms used for relating electrical potentials, that
ar generated by visual stimuli. These short stimuli ar
recorded from the scalp, superjacent the cortical area.
By signal averaging, electroencephalogram is that the
technique usually utilized to capture and record the
VEP waveforms. VEPs area unit} most significantly
wont to measure the visual pathways’ purposeful
integrity from the membrane, via the optic nerves, up
to the cortical area within the brain. many studies are
conducted to guage the consequences of
anticonvulsant medication on the visual pathway by
mensuration VER. the aim of this study was to elicit a
potential relationship between VER connected
abnormalities among brain disease patients and
therefore the range of anticonvulsant medication being
taken. give a outline of the age-wise distribution of the
epileptic patients (cases) and controls enclosed within
the study. In (0 to 25) thirty two.1% management
compared to five.8% patients ontriple medical aid,
11.5% double medical aid, and 12.2% on
This work is partly presented at 4th Global Congress on Spine and spinal Disorder September 5-6, 2018 Auckland New zeland
Extended Abstract
Vol. 3 Iss.3
2019
Journal of Psychology and Brain Studies
monotherapy. In social class (25 to 50), 13.5%
management is compared with three.5% of patients
ontriple medical aid, 3.2% double medical aid, and
9.0% on mono medical aid. In age ( ≥ 50),5.8%
management compared with one.3% double medical
aid, and 1.9% patients on mono medical aid. showed a
statistically vital distinction within the mean countless
Latency P100, between the male and feminine case
cluster subjects. No vital distinction was noted with
relevance the mean countless Latency N75 and
Amplitude P100. Upon comparison the mean countless
the management cluster.

Author(s): Alshareef Aysha,

Abstract | PDF

Share This Article