Synthesis of Novel N-acetyl-(3-substituted-1H-pyrazole-(4H)- 5-on)-yl-1,2,3,4-tetrahydrocarbazole and its antimicrobial studies

A new family of Novel N-acetyl-(3- substituted-1H-pyrazole-(4H)-5-on)-yl-1,2,3,4-tetrahydrocarbazole 4(a-e) were prepared by the cyclocondenstion of N-(hydrazino acetyl)-1,2,3,4-tetrahydrocarbazole 2 with series of substituted β- ketoesters3(a-e). The compound N-(hydrazino acetyl)-1, 2, 3, 4-tetrahydrocarbazole was prepared by the condensation of N-(chloroacetyl)-1, 2, 3, 4-tetrahydrocarbazoles 1 with hydrazine hydrate. The titled compounds have been characterized on the basis of analysis of IR, HNMR and MASS spectroscopy. All the titled compounds 4(a-e) were screened for antibacterial and antifungal activities

Author(s): T. Surendiran

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