Fluoronitro benzothiazoles are an interesting group of compounds with a wide range of biological activities. In present work an effort has been done to find suitability and feasibility of different synthetic methods available in the literature for the preparation of fluoro-nitrobenzothiazole derivatives (or by Retro-synthetic approach). Attachment of thiazolidine in fluoro-nitrobenzothiazole ring system, has been tried in thought that it could enhance the activity of benzothiazole and other derivatives . Based on the above observations, we have synthesized some fluorobenzothiazole derivatives in hope of getting new pharmacological agents with broad spectrum of clinical activity. Compounds 9d, and 9e have shown moderate activity against Staphylococcus aureus. Compounds 9b, and 9d have shown moderate activity against Bacillus subtillis. The synthesized compounds 9a, 9c and 9e were found to possess moderate anti-inflammatory activity when compared to Diclofenec sodium. The study regarding anti oxidant activity shown that synthesised compounds are not anti-oxidants.
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