Synthesis, characterization and in vitro drug delivery of nanostructured Fe-doped hydroxyapatite bioceramics

Bioactive nanocrystalline Fe doped hydroxyapatite (Fe: HAP) were successfully prepared through auto-combustion route. The synthesized samples were characterized by various physico-chemical methods. Thermal stability investigated using thermo-gravimetric and differential thermal analysis (TG-DTA). Structural characterizations of the samples were carried out by the X-ray diffraction technique (XRD). Phase formation of Fe-HAP was determined by fourier transform infrared spectroscopy (FTIR). The obtained multifunctional Fe doped HAP samples were performed as a drug delivery carrier to investigate the drug storage/release properties using norfloxacin as a model drug. The results reveal that the multifunctional Fe-HAP exhibits the typical hexagonal structure, and have crystallite size of 30–25 nm. The drug storage/release test indicates that the Fe-HAP shows higher drug loading amount and cumulative release rate to those of pure HAP. In summary, this work has demonstrated the potential to produce Fe-HAP as a carrier for drug delivery for bone regeneration and other biomedical applications

Author(s): Pramod N. Jagadalea, Pramod P. Jagtapb, Sambhaji R. Bamanec

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