Synthesis and characterization of organophosphorous dihydro pyrimidinone derivatives

Dihydropyrimidinone’s (DHPMs) is a nitrogen containing heterocyclic ring which possesses biological and pharmaceutical importance. One-pot multi component syntheses of DHPMs have been achieved from aromatic and aliphatic aldehyde, ethylacetoacetate and urea under solvent free condition. This method is really easy and shorter time duration for the synthesis of DHPMs derivatives. Citric acid acts as a natural catalyst in the present investigation. The DHPMs derivatives were further treated with phosphorous Oxy chloride to obtain organo phosphorous compound. The formations of the compounds were characterized by FTIR, 1HNMR and 31PNMR.The antibacterial activity among aliphatic and aromatic substituted based dihydropyrimidinone have also been prepared and compared.

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