Some new substituted 3-((4-(-phenyl) thiazol-2-yl) amino)-2-isopropylquinazolin-4(3H)-one (III) have been synthesised from different hydrazinyl thiazole derivatives (I) by condensing with 2-isopropyl-4Hbenzo[ d][1,3]oxazin-4-one (II). Their chemical structures have been confirmed by IR, 1H NMR, and MASS and by elemental analysis. Investigation of antimicrobial activity of compound was done by the disk diffusion technique. Among the compound with -F,-Cl and –NO2 substitution showed the most favourable antimicrobial activity.
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