Synthesis and anti-cancer activity of new thiosemicarbazones of 1-(5-chloro 1H-benzimidazol-2-yl) ethanone

Some new Thiosemicarbazones containing Benzimidazole moiety were synthesized by combination of conventional as well as green chemistry methods, which had potential Anti – tumor activity against various cancerous cells. All the compounds were submitted to National Cancer Institute, USA for in vitro anti-cancer screening against 60 human cancer cell lines. Our one compound S2 (NSC 92491) was selected for five dosage screening and showed remarkable activity.

Author(s): Hitesh D. Patel and Saavani A. Shah

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