Study on responses of C-peptide and blood glucose for Carbohydrate 70g in diabetes

Background: Discussion concerning Carbohydrate Restriction (CR) and Low Carbohydrate Diet (LCD) has been continued. Authors formerly proposed insulinogenic index-carbohydrate 70 g (IGI-carbo70). Along this, C-peptide index for Carbohydrate-70 g (CPI-Carbo70) is studied.

Subjects and Methods: Subjects were 46 patients (62.5 yo. in average) with Type 2 diabetes mellitus (T2DM) and admitted for evaluation. CR diet was given on day 1-2 with 60% carbohydrates, 25% lipids and 15% protein with 1400 kcal/day. On day 2, breakfast with Carbo70 was given, and glucose and C-peptide (CP) were measured at 0 and 30 minutes and analyzed.

Results: As basal data, average HbA1c was 8.1%, median HbA1c, average daily glucose, median M value was 7.7%, 187 mg/dL, 71, respectively. In response to Carbo70, median values of glucose-0, glucose-30, delta-glucose, CP-0, CP-30, delta-CP was 142, 186, 22 mg/dL, 0.9, 1.4, 0.4 ng/mL, respectively. CPI-Carbo70 was 1.54 in median. There were significant correlation between glucose and-CP on 0, 30min, delta-0-30min (p<0.01). Significant correlation was observed between CPI and HbA1c, CPI and M value (p<0.01).

Discussion and Conclusion: CPI-Carbo70 might be useful for evaluating pancreas function and glucose variability in clinical research. Current data would become the fundamental data for the future diabetic practice and research development. 

Author(s): Hiroshi Bando*, Koji Ebe, Tetsuo Muneta, Masahiro Bando and Yoshikazu Yonei6

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