Structural Analysis of Mycobacterium Tuberculosis Mutations to Investigate the Role in Antibiotic Drug Resistance

Multidrug-resistant tuberculosis (MDR-TB) is among the most troubling component of the pandemic of anti-microbial resistance since TB patients that fail treatment have a high peril of death. Extensively drug-resistant tuberculosis (XDR-TB) has emerged as a major public health problem worldwide. Multidrug-resistant (MDR) Mycobacterium tuberculosis strains are resistant to at least the first-line antituberculotic drugs, rifampin (RIF) and isoniazid (INH), which are the mainstay of short-course chemotherapy for tuberculosis. Drug resistance arises when mutations, or chromosomal replication errors, occur in genes that encode sedate targets or drug metabolism mechanisms and effect the adequacy of hostile to tuberculosis treatments M. tuberculosis uses various mechanisms, including mutations in genes that code for drug target genes and become resistant to drugs and therefore, better comprehension of the molecular mechanism and genetic basis of development of resistance to drugs used in chemotherapy is required. Thus, in this study structural analysis of Mycobacterium Tuberculosis mutations is done to study protein-ligand interactions and thus highlight binding trends. Several mutations in different mycobacterium tuberculosis strains has been reported from different regions around the world. Mutations associated with multi/extensive drug resistance has been identified from literature and "The Comprehensive Antibiotic Resistance Database". Table 1 elaborated the data of some of the most frequent mutations

Author(s): Muhammad Sibte Hasan Mahmood

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