Stereo Chemistry Explain the Activity Toxicity and the Pharmacological Action of Many Drugs

Many drugs differ in pharmacological action according to their stereochemistry. The quinine used as antimalarial while quinidine used as antiarrhythmic, dextro cyclophosphamide is toxic while the levo is anticancer, dextro ketamine used as general anathesia while levo ketamine is agitation agent, dextro secobarbital is anticonvulsant while levo secobarbital is anesthetic, levodopa is antiparkinsonism while dopa is a granulocytosis, levamisole is safe anthelmintic while tetramisole has many side effects and less active, Thalidomide the (R) form more safe than (S) form which is tratogenic, the cisplatin is more active than the trans form, the levo adrenaline is more active than dextro form the diethylstilbosterol the transform is more active than cis form.

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