Stem cell regenerative medicine is the fastest growing branch of clinical medicine and it has a tremendous role in Orthopedics. All orthopedic surgeries need implants of metal in the form of screws unipolar, bipolar implants, cages, artificial cervical disc, plates etc. After getting these metallic implants, our Bony tissues tend to face Heterotopic ossification and other complications. Problem with hardware implant is that, they can't work exactly as like our own organs & system, for instance hip arthroplasty can't be a substitute for original hip joint & ultimately patients may get decreased or limited mobility in joints & even implant failure might occur. Second problem is that even after successful surgical procedures we need a long time rehabilitation time to mobilise as a normal person. This is why we need regenerative medicine in the field of orthopedics, under which we can regenerate the damaged bone tissue, cartilage, tendon etc.in order to sustain the normal & efficient function of musculoskeletal system. The presented review aims to discuss all the potential benefits of SCRM in Orthopedics.