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Abstract

Seroprevalence of Human Parvovirus B19 Antibodies among Sudanese Patients with Rheumatoid Arthritis

Background: In order to find a relationship between the Parvovirus B19 and the extent of its relation with Rheumatoid Arthritis, it was decided to carry out this study with the objective to determine the seroprevalence of both IgM and IgG anti- Parvovirus B19 among Sudanese patients with Rheumatoid Arthritis.
Methods: it was cross sectional hospital based study. 90 blood samples were collected from known Sudanese patients who visited the rheumatology clinic of different hospitals in Khartoum – SUDAN and fulfilled the American College of Rheumatology Criteria for Rheumatoid Arthritis in the period between April and July 2014. The anti-citrullinated cyclic peptide (ACCP) and rheumatoid factor (RF) were done to all patients and ELISA technique was used for detection of IgG and IgM anti-parvovirus B19 in patients' serum.
Result:
The results presented herein show the presence of IgM anti-parvovirus B19 in 31 (34.4%) of RA examined patients (27 (30%) female and 4 (4.4%) male). The IgG was detected in 49 (54.4%) of the study subjects (40 (44.4%) female and 9 (10%) male).
Conclusion:
our study extends and agrees with the previous observations regarding a high prevalence of B19 antibodies in patients with RA, and a possible role of its infection in the pathogenesis of RA. We recommend the researchers to search in depth at molecular level about the possible relations between parvovirus B19 and RA in Sudanese patients.


Author(s): Mohammed I ELsedig*, Wafa Elhag, Mohammed J.El-Mak, Mohammed Abbas

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