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Safety Profile and Therapeutic Effectiveness of Klebsiella pneumonia Bacteriophages Using Acute and Sub-Chronic Animal Toxicity Study

Recently, numerous pre-clinical and clinical studies have shown their significant phage therapy efficacy against many antibiotic resistant pathogens and proved to be one of the best alternatives to the antibiotics. Bacteriophages can also be used as biocontrol agents in agriculture and petroleum industries. However, only few researchers have focused to monitor the phage-mediated acute immune reactions during phage therapy. Besides, phage safety was evaluated by determining toxicity after acute and sub-chronic oral administration of low and high dose of bacteriophages in male and female rodents. 

Author(s): Mayank Gangwar

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