Abstract

Role of Picotechnology and Nanotechnology for Personalized Medicine and Healthcare

The aim is to use Nanotechnology and nanomaterials/ biomaterials for development of non invasive diagnostics and for therapeutic applications. Several rare earth based functionalized nanomaterials were developed for targeted drug delivery and contrast agents for magnetic resonance imaging for the diagnosis of early stage cancer in mice models. The study was extended to evaluating their compatibility, stabilization in blood after injection, pharmacological studies to understand the clearance and shelf life in the body. The other part of the work focuses on fabrication of nanomaterials based membranes for device applications, for example fabrication of nanomaterial composites for removal of uremic toxins from dialysates to make dialysis faster and the fluid reusable. This is going to be a boon for people suffering from chronic kidney diseases and people with diabetes which ultimately lead to kidney failure. Besides, the imbalance in gut microbiota (dysbiosis) develops a highly permeable intercellular epithelial junctions leading to translocation of harmful microbes and toxins into the blood. We are attempting to balance the gut microbiota by a series of our products instilled with probiotics. If required we can perform the shortgun sequencing studies to understand the diversity of the microbes in the gut responsbile for the diseased condition. Patients respond differently to different drugs. No patients have the same response to a particular drug molecule. It is therefore very challenging to determine which drug or combination of drugs should be given to a particular


Author(s): Ranu Dutta

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