Increasing evidence indicates the derangement of poly- unsaturated fatty acid (PUFA) mediated membrane function in the pathophysiology of schizophrenia. Various preclinical studies and clinical trials on non-psychiatric population have identified the anti-inflammatory properties of omega-3 fatty acids (FA). Even though early intervention with omega-3 supplementation is considered in various psychiatric disorders, their biologically role in psychosis is not clearly understood. In this study, we investigated the influence of omega-3 supplementation on peripheral immune markers in an ultra-high-risk (UHR) population. We quantified 15 inflammatory cytokines at baseline (n=265) and at follow-up (n=171) in plasma samples of UHR subjects.