Regenerative approach toward Peripheral Nerve Injuries

Peripheral nerves injuries occur frequently. They constitute a major cause of disabilities. Injuries affecting the peripheral nervous system Impairs the ability to move muscles, to feel normal sensation and must often result in chronic painful neuropathies. Peripheral nerve injuries can be traumatic,n on traumatic or surgical in nature, however the most challenging of them of all is the traumatic and surgical injuries. Traumatic and surgical peripheral nerve injuries posed immense challenge in their treatment modalities; they are also associated with poor clinical outcome. The simplest technique for nerve repair is co-amputation of the two ends of the nerve using sutures or fibrin glue, but this technique has its own limitation because in many case of nerve transection, there is loss of nerve segment and most often there is a time lag between injury and surgical repairs, which can lead to nerve end retraction, resulting in the formation of nerve gap. When nerve gap is formed, suturing the end to end of the nerve will lead to the creation of tension along the nerve segment, which results in poor regenerative outcome.

Author(s): Ruben Gombalandi

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