Nature provides rich sources of structurally diverse phytochemicals with medicinal relevance and biological activities. Sodium arsenite has been recognized as a worldwide health concern due to its teratogenicity effects on animals. Natural plants are considered as a possible protective agent against arsenic induced toxicity. The aim of this study was to investigate the protective effects of Delonix regia leave extracts on sodium arsenite induced hepatotoxicity in rat. Animals were randomly divided into six groups of five per group. Group A (control) received distilled water for fourteen (14) days. Group B received 2.5 mg/kg body weight Sodium Arsenite, group C received 100 mg/kg of leave extract and 2.5 mg/kg of sodium arsenite, Group D received 400 mg/kg of leave extract and 2.5 mg/kg of sodium arsenite, Group E received 100 mg/kg of leave extract, Group F received 400 mg/kg of leave extract only. On the fourteen day all the animals were sacrificed. Biochemical parameters such as plasma Alanine amino transferase (ALT), Aspartate amino transferase (AST) Alkaline phosphate (ALP) and gamma glutamyl transferase (GGT) total protein (TP) were evaluated. Sodium arsenite in rat triggers significant increase in ALT, AST, ALP, TP, and GGT (p<0.05 level). Upon treatments with Delonix regia leave extract, it decreases the concentration of GGT, AST and ALP compared to the negative control. Group treated with the extract alone showed no adverse effects on the liver parameters. Results from this study suggest that, the administration of Delonix regia leave extract confer some protective effects on the liver.