Preparation and Evaluation of Wound Healing Activity of New Polyherbal Formulations in Rats

The aim of present study was to evaluate the wound healing activity of newly prepared polyherbal formulations ( i ,e Ointment, Gel and Liquid ) in Excision and Incision wound models in rats. The woundhealing activity was assessed by the rate of wound contraction, period of epithelialization and skin-breaking strength. In Excision wound model the polyherbal Ointment treated group exhibit 99.78±0.11% reduction in wound area on 20th day when compared to standard Betadine Ointment and controls which was 98.55±0.44 % and 90.12±0.27% and faster rate of epithelization (16.55 ± 0.46). In the incision wound model, there was a significant increase in tensile strength (538.10± 1.52) was observed in ointment treated group. In all cases, there was a progressive decrease in wound area with time, indicating an efficacy of the formulations in healing the induced wounds. Our present study reveals that the new polyherbal formulations posses potent wound healing activity, which could be a good choice of remedy for wound healing.

Author(s): Ansar M. Patel, S.M. Kurbetti, R.V.Savadi, V.A. Thorat , V. V. Takale , S.V. Horkeri

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