Severe traumatic brain injury (TBI) is related to a high mortality and morbidity rate and is one amongst the leading causes of death within the medical care units. The aim of this study was to look at predictors of hospital outcome in adult patients admitted to ICU attributable to severe TBI. Methods: A retrospective study was carried on patients (n=621) with severe head injury, outlined as port Coma Scale (GCS) ≤ eight World Health Organization were admitted to the final ICU over a 15-year amount (1999-2013). most significant variables that might be correlate with outcome (demographics, explanation for injury, GCS, clinical variables and computed tomography–CT scan) were analysed. Results: Total death rate was twenty seven.38%. Patients older than seventy five years had a death rate of fifty seven.14%. 70.05% of the patients were male and sixty one.99% of cases were thanks to traffic accidents. coexistent injuries, found in fifty two.98% of the patients aggravated the prognosis. Shock developed in seventeen.23% of the patients and drive in twenty seven.38% were particularly exacerbating factors. Outcome is extremely correlate with GCS’ values. CT scan findings unconcealed that patients with acute epidural hematomas recorded a death rate of V-day whereas those with meninges hematomas forty three.75%. The six-month overall smart outcome, supported port Outcome Scale (GOS) was thirty seven.03%. Conclusions: Severe TBI encompasses a high mortality and morbidity in Greek society because it encompasses a high negative impact on adolescents, particularly men. The age of the patient, GCS at admission and also the CT scanning square measure important predictors of outcome (p ≤ zero.05). a big proportion of patients were still dependent for care at six-month post-injury assessment.