Predictive Value of First Trimester Measurements of Adiponectin and 1,5 Anhydroglucitol in Diagnosis of Gestational Diabetes Mellitus

Background: The search for diagnostic biomarkers in diabetes is rapidly expanding, increasing efforts devoted to new diabetes diagnostic biomarker discovery. Current, early screening and diagnostic tests for D.M. depend on studies on biomarkers.

Aim of the work: The current research aimed to predict the occurrence of gestational diabetes by measuring serum adiponectin and 1, 5 anhydroglucitol during the first trimester.

Methods: OGTT was done using 75 g of anhydrous glucose, which was given to the pregnant women, and measurement of 1,5 AG was simultaneously performed to all cases in the first, and ≥ 24 weeks of their pregnancy, respectively. Serum 1, 5, A.G. and adiponectin levels were assessed using an enzymatic, colorimetric assay kit by ELISA method.

Results: 1,5 AG and adiponectin concentrations were significantly lower in women with high-risk for GDM during the first trimester. The area under the ROC curve was 0.968 for 1,5 A.G, and 0.737 for adiponectin. The maximal sensitivity and specificity (100% and 80%, 100% and 66.7% for 1,5 A.G. and adiponectin respectively). A 1,5- AG cut-off level of 1,5 A.G was 7.55 µg/mL and 17.30 for adiponectin.

Conclusion: We concluded that first-trimester measurement of serum 1,5 anhydroglucitol concentration and adiponectin is a good biomarker for GDM, and 1,5 A.G. is the most reliable.

Author(s): Merhan Mabad Abd Elazez Salem, Amal Abdel-Samae El-Sokary, Sahar Mohey ElDin Hazzaa*, and Mohamed Nabih El-Gharib

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