Phytochemical investigation and anthelmintic activity of various root extracts of Gmelina arborea Roxb.

Helminthes have been common cause of concern and pose many problems to human beings and animals. Many medicinal plants claimed to possess anthelmintic activity. Gmelina arborea belonging to Verbenaceae locally named as Gambhari (Oriya) was traditionally used to treat Helminthia. The objective of present work was to phytochemical investigation and evaluate the anthelmintic activity of ethanol, ethyl acetate, n-butanol and petroleum ether extract of root of Gmelina arborea using Indian earthworms Pheretima posthuma as test worm. Various concentrations of each extracts were tested. which involved determination of paralysis time and death time of the worm. albendazole. (60mg/ml) was used as a reference standard. The result of present study indicates that. Among all the extract, ethanol and petroleum ether showed dose dependent & significant anthelminitic activity. petroleum ether showed better activity as compared to reference drug albendazole. The data were verified as statistically significant by using One way ANOVA followed by Dunnet’s test. Values are mean ± S.E.M. n = 6 in each group.*P< 0.05 when compared to standard.

Author(s): Sangram K. Panda*, Debajyoti Das and Niraj K. Tripthathy

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