Nigerians are facing a serious global environmental problem and there is a widespread concern that the ozone layer which is bringing out terrible deterioration thus contributes to climatic change and global warming. This study made use of relevant already published data of the nature and effect of climate change in Nigeria. The objective of this paper is to review and examine how ozone layer depletion and climate change acts as a threat to Nigerians and strategies that should be elucidated to reduce this phenomenon. The review established the fact that climate change has adverse effect in Nigeria especially in gas flaring region, Nigeria Delta area. Nigeria generally is known as a highly industrialised country and a recent study reports that Nigeria have over one hundred and twenty three (123) gas flaring sites making her one of the highest emitters greenhouse gases in Africa. The World Bank (2008) revealed that Nigeria accounts for roughly one-sixth of worldwide gas flaring. There are sparse rainfall thereby making food production difficult in Northern part of Nigeria, Uncontrolled logging, people in Niger Delta region are experiencing oil exploration and exploration, deforestation and bush burning in the southern Nigeria leading to acid rain, urbanization with increasing risk of disease and rising cost of extreme weather damage. The impacts of which are already felt all over the country.