The techniques used for extraction since decades have the limitations of requiring longer extraction times, large solvent volumes and cause degradation of thermo labile components. Modern methods of extraction are effective in advancing the development of traditional herbal remedies. Various novel techniques including ultrasonicationassisted extraction, microwave-assisted extraction,counter-current extraction and accelerated solvent extraction have been developed for the extraction of nutraceuticals from plants in order to shorten the extraction time, decrease the solvent consumption, increase the extraction yield, and enhance the quality of extracts. A new advancement in the field of extraction was introduction of “Phytonics Process”, a new solvent based on hydrofluorocarbon-134a technology used for extraction of fragrant components of essential oils and biological or phyto-pharmacological extracts which can be used directly without further physical or chemical treatment. The present article portrays a comprehensive discussion on principles, methodology, benefits and applications of these innovative extraction technologies for procuring active metabolites from different phytoconstituents.