miRNA analysis in insulin resistant and T2D patients in Qatari population

Background and Objective Insulin resistance (IR) is type 2 diabetes (T2DM) hallmark. MiRNAs regulate many target genes which makes them attractive candidates for regulating insulin production,secretion and action. Thus, if miRNAs play a role in the pathogenesis of IR, we anticipate a change in the circulatory profile of miRNAs in IR subjects compared to normal glucose tolerance subjects. In the present study, we sought to identify the circulating miRNAs associated with IR as biomarkers in Qatari population. The circulating miRNA profile was assessed in a pilot study of healthy volunteers (n=22) whose insulin sensitivity was quantitated by euglycemic hyperinsulemic clamp. Moreover, in the validation phase (n=40) subjects were added including lean and obese T2D.

Author(s): Khaoula Errafii, Said Boujraf, Mohamed AbdulGhani, Mohamed Chikri

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