Abstract

Methanol stem extract of Moringa oleifera mitigates glycerol-induced acute kidney damage in rats through downregulation of KIM-1 and NF-kB signaling pathways

Acute kidney injury was projected to replace acute renal
failure as a means to improve clinical diagnosis of the disease.
It is associated with nephron loss and a subsequent
loss of renal function and there are still no effective drugs
to treat this condition [1]. It is typically defined as the reduction
in the functional ability of the kidneys to excrete
salt, water and metabolic waste products such as creatinine
[2]. Acute renal failure (ARF) is a syndrome distinguished
by an acute loss of renal function. Mortality from
ARF remains high (over 50%), despite the reversibility
of this loss in most patients who survive. It is characterized
by a rapid, potentially reversible, decline in renal
function including rapid fall in glomerular filtration rate
(GFR), and retention of nitrogenous waste products over
a period of hours or days [3]
Moringa oleifera popularly referred to as wonder plant is
a medicinal plant with a remarkable variety of therapeutic
purposes. The aim of this study was to assess the ameliorative
effect of Moringa oleifera on glycerol-induced
acute kidney injury in rats thus renewing interest in the
development of new treatment plans. Glycerol (50% v/v
in sterile saline, intramuscular) was used to induce acute
kidney injury. Group A (control group) received distilled
water only, the group B animals (toxicant group) received
glycerol alone on the 8th day, and groups C and D animals
were given 50 mg/kg and 100 mg/kg of methanol
stem extract of Moringa oleifera respectively for seven
days and glycerol on the 8th day. Group E animals on the
other hand received 100 mg/kg of methanol stem extract
of Moringa oleifera alone for seven days and on day 8
received normal saline.


Author(s): Adeolu Alex Adedapo

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