Invitro alpha amylase and alpha glucosidase inhibition activity of crude ethanol extract of Cissus arnottiana

Diabetes mellitus is one of the most common endocrine diseases characterized by hyperglycemia due to absolute or relative deficiency of insulin. One anti diabetic therapeutic approach is to reduce gastrointestinal glucose production and absorption through the inhibition of alpha amylase enzyme plays a major role in preventing rise in postprandial glucose level in diabetics. The main aim of the current study was to screen the ethanol extract of Cissus arnottiana fruits for its in vitro alpha amylase and alpha glucosidase activity. The preliminary phytochemical screening of this plant crude ethanol extract showed presence of maximum compounds, hence the ethanol extract have under taken for its alpha amylase and alpha glucosidase inhibition activity. All the tested concentrations of extract of C. arnottiana showed significant inhibitory activity. At the concentration of 10mg/ml the plant showed appreciable alpha amylase and alpha glucosidase inhibitory activity (78.91%, 81.25%) with IC50 value 2.95mg, 2.81mg respectively.

Author(s): Kavitha Sama, Kamaraj Murugesan* and Rajeshwari Sivaraj

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