Influence of combined physical exercise on cognition and modulation of epigenetic markers in institution alized elderly

The elderlypopulationhasincreasedexponentially in recentdecades. Withthis, manyelderlypeopleunabletoliveindependently start tolive in long-terminstitutions. Evidencesuggeststhatepigeneticfactors, mainlyreducedlevelsofhistoneacetylation and theBrainDerivedNeurotrophicFactor (BDNF) in thehippocampus, are associatedwiththeagingprocess and theemergenceofneurodegenerativediseases. The practiceofphysicalexerciseis a non-pharmacologicalstrategycapableofminimizing and preventingcognitiveimpairment, improvingmemory and learning processes. Studiesdemonstratethebenefitsofthispractice in institutionalizedelderlypeople, butthe molecular mechanismsinvolved are still unclear. Objective:toevaluatetheeffectof a combinedexerciseprotocoloncognition

Author(s): Iasmin Borges Fraga

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