In silico Analysis of Structure Activity Relationship of -Conotoxins with Cav 2.2 Channel Receptor for Treatment of Neuropathic Pain

The N-type voltage-gated Ca2+ channel Cav2.2 is expressed predominantly at presynaptic neuronal terminals. They are predominantly expressed in nerve terminals, where they control neurotransmitter release. Also, this receptor transduces electrical activity into other cellular functions and plays an important role in processing pain information in nociceptive pathways. To date, genetic and pharmacological studies have identified that high threshold, Cav 2.2 channel receptor is important for pain sensation in disease models. This suggests that Cav 2.2 channel receptor inhibitors or modulators could be developed into useful drugs to treat neuropathic pain. Thus, they are molecular targets for pharmacological agents as well as for broad range of potent neurotoxins. Cav 2.2 channels are reported as main target of ω-conotoxins

Author(s): Muhammad Sibte Hasan Mahmood

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