Formulation and Evaluation of Mouth Dissolving Tablets of Diltiazem Hydrochloride

In this investigation mouth dissolving tablets of Diltiazem hydrochloride were prepared using different superdisintegrants by wet granulation method. MDTs were evaluated for physicochemical properties and in vitro dissolution. Effect of disintegrant on disintegration behavior of tablet in pH 6.8 was evaluated. Wetting time of formulations containing higher concentration of Crospovidone was least and tablets showed fastest disintegration. The drug release from MDTs increased with increasing concentration of superdisintegrants and was found to be highest with formulations containing Crospovidone.

Author(s): Suryakant B. Jadhav , Dinesh M. Sakarkar, Datta R. Kaudewar , Girish S. Kaminwar and Rajesh V. Kshirsagar

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