In this study synergistic activity on the root of Hemidesmus indicus (family: Apocynaceae) and leaf of Terminalia catappa (family: combretaceae) on rheumatoid arthiritis model were studied. Investigations was performed using the phlogistic agent such as Carrageenan-induced paw edema in rats. Ethanolic extracts on root of Hemidesmus indicus and leaves of Terminalia catappa at a dose of 200 mg/kg and 400 mg/kg orally were tested. Diclofenac sodium at the dose of 100mg/kg was used as standard. Both the extracts showed significant activity (*p<0.05 & **p<0.01, ***p<0.001) compared with the control and showed a significant % of reduction (80%) in Carrageenan induced rat paw edema model. Thus it is revealed from the screening model that the two different plants extract possess synergistic anti-inflammatory activity.