Abstract

Evaluation of Antidiabetic activity of Costusigneus(L) leaves on STZ induced diabetic rats

The aim of this research was to investigate antidiabetic activity of Costus igneus (also known as insulin plant) leaves extracts in streptozotocin induced diabetic albino rats. A comparison was made between the action of Costus igneus extract and a known antidiabetic drug glibenclamide (5mg/kg body wt.). An oral glucose tolerance test (OGTT) was also performed in experimental diabetic rats. Ethanolic and aqueous extracts of Costus igneus(L) were obtained by simple maceration method & were subjected to standardization by phytochemical screening methods. Preliminary phytochemical investigations showed the presence of alkaloids.flavonoids,phenolic compounds and steroids in ethanolic extract. Dose selection was made on the basis of acute oral toxicity study (50mg to 2000 mg/kg body weight) as per OECD guidelines423. The ethanolic extract of Costus igneus showed significant (P<0.001) antidiabetic activity. This extracts also prevented body weight loss in diabetic rats


Author(s): M.V. Kumudhavalli and B. Jaykar

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